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Table of Contents
 
 
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
 
 
FORM
 10-Q
 
 
(Mark One)
QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended June 30, 2020
OR
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from
                    
to
                    
Commission file number:
001-37539
 
 
Global Blood Therapeutics, Inc.
(Exact name of registrant as specified in its charter)
 
 
 
Delaware
 
27-4825712
(State or other jurisdiction of
incorporation or organization)
 
(I.R.S. Employer
Identification No.)
181 Oyster Point Boulevard
South San Francisco, CA 94080
(Address of principal executive offices)
(650)
741-7700
(Registrant’s telephone number, including area code)
 
 
Securities registered pursuant to Section 12(b) of the Act:
Title of each class
 
Trading
Symbol(s)
 
Name of each exchange
on which registered
Common Stock, par value $0.001 per share
 
GBT
 
The NASDAQ Global Select Market
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  
    No  
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation
 S-T
(§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).    Yes  
    No  
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a
non-accelerated
filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule
 12b-2
of the Exchange Act.
Large accelerated filer
 
 
Accelerated filer
 
             
Non-accelerated
filer
 
 
Smaller reporting company
 
             
 
 
Emerging growth company
 
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  
Indicate by check mark whether the registrant is a shell company (as defined in Rule
 12b-2
of the Exchange Act).    Yes  
    No  
As of July 31, 2020, there were 61,360,776 shares of the registrant’s Common Stock, par value $0.001 per share, outstanding.
 
 

Table of Contents
TABLE OF CONTENTS
 
 
 
 
  
Page
 
  
 
3
 
     
Item 1.
 
  
 
3
 
 
 
  
 
3
 
 
 
  
 
4
 
 
 
  
 
5
 
 
 
  
 
7
 
 
 
  
 
8
 
Item 2.
 
  
 
18
 
Item 3.
 
  
 
27
 
Item 4.
 
  
 
27
 
   
  
 
28
 
     
Item 1.
 
  
 
28
 
Item 1A.
 
  
 
28
 
Item 2.
 
  
 
66
 
Item 3.
 
  
 
66
 
Item 4.
 
  
 
66
 
Item 5.
 
  
 
66
 
Item 6.
 
  
 
66
 
   
  
 
68
 
2

Table of Contents
PART I. – FINANCIAL INFORMATION
Item 1.
Financial Statements
GLOBAL BLOOD THERAPEUTICS, INC.
Condensed Consolidated Balance Sheets
(In thousands, except share and per share amounts)
 
June 30, 2020
 
 
December 31, 2019
 
 
(Unaudited)
 
 
 
Assets
 
 
 
 
 
 
Current assets:
   
     
 
Cash and cash equivalents
  $
384,716
    $
302,237
 
Short-term marketable securities
   
156,014
     
307,732
 
Accounts receivable, net
   
12,471
     
2,637
 
Inventories
   
27,334
     
1,277
 
Prepaid expenses and other current assets
   
13,498
     
14,114
 
                 
Total current assets
   
594,033
     
627,997
 
Property and equipment, net
   
39,668
     
27,113
 
Long-term marketable securities
   
33,479
     
85,030
 
Operating lease
right-of-use
assets
   
51,580
     
52,775
 
Restricted cash
   
2,395
     
2,395
 
Other assets, noncurrent
   
512
     
789
 
                 
Total assets
  $
721,667
    $
796,099
 
                 
Liabilities and Stockholders’ Equity
 
 
 
 
 
 
Current liabilities:
   
     
 
Accounts payable
  $
5,690
    $
10,621
 
Accrued liabilities
   
43,733
     
41,358
 
Accrued compensation
   
16,463
     
17,578
 
Other liabilities, current
   
3,516
     
1,896
 
                 
Total current liabilities
   
69,402
     
71,453
 
Long-term debt
   
73,775
     
73,559
 
Operating lease liabilities, noncurrent
   
81,903
     
72,359
 
Other liabilities, noncurrent
   
771
     
34
 
                 
Total liabilities
   
225,851
     
217,405
 
                 
Commitments and contingencies
   
     
 
Stockholders’ equity:
   
     
 
Preferred stock, $0.001 par value, 5,000,000 shares authorized as of June 30, 2020 (unaudited) and December 31, 2019; no shares issued and outstanding
   
—  
     
—  
 
Common stock, $0.001 par value, 150,000,000 shares authorized as of June 30, 2020 (unaudited) and December 31, 2019, respectively; 61,330,987 and 60,644,380 shares issued and outstanding as of June 30, 2020 (unaudited) and December 31, 2019, respectively
   
61
     
61
 
Additional
paid-in
capital
   
1,359,310
     
1,316,795
 
Accumulated other comprehensive income
   
1,227
     
754
 
Accumulated deficit
   
(864,782
)    
(738,916
)
                 
Total stockholders’ equity
   
495,816
     
578,694
 
                 
Total liabilities and stockholders’ equity
  $
721,667
    $
796,099
 
                 
See accompanying notes to unaudited condensed consolidated financial statements.
3

Table of Contents
GLOBAL BLOOD THERAPEUTICS, INC.
Condensed Consolidated Statements of Operations and Comprehensive Loss
(Unaudited)
(In thousands, except share and per share amounts)
 
Three Months Ended June 30,
   
Six Months Ended June 30,
 
 
2020
 
 
2019
 
 
2020
 
 
2019
 
Product sales, net
  $
31,501
    $
—  
    $
45,619
    $
—  
 
Costs and operating expenses:
   
     
     
     
 
Cost of sales
   
377
     
—  
     
512
     
—  
 
Research and development
   
34,085
     
36,010
     
73,858
     
70,476
 
Selling, general and administrative
   
49,075
     
24,794
     
96,736
     
42,849
 
                                 
Total costs and operating expenses
   
83,537
     
60,804
     
171,106
     
113,325
 
                                 
Loss from operations
   
(52,036
)    
(60,804
)    
(125,487
)    
(113,325
)
Other income (expense):
   
     
     
     
 
Interest income
   
1,514
     
3,706
     
4,370
     
7,537
 
Interest expense
   
(2,282
)    
(160
)    
(4,596
)    
(341
)
Other expenses, net
   
(36
)    
(63
)    
(153
)    
(115
)
                                 
Total other income, net
   
(804
)    
3,483
     
(379
)    
7,081
 
                                 
Net loss
   
(52,840
)    
(57,321
)    
(125,866
)    
(106,244
)
Other comprehensive loss:
   
     
     
     
 
Net unrealized gain on marketable securities, net of tax
   
12
     
615
     
472
     
1,239
 
                                 
Comprehensive loss
  $
(52,828
)   $
(56,706
)   $
(125,394
)   $
(105,005
)
                                 
Basic and diluted net loss per common share
  $
(0.86
)   $
(1.01
)   $
(2.06
)   $
(1.88
)
                                 
Weighted-average number of shares used in computing basic and diluted net loss per common share
   
61,116,707
     
56,539,760
     
60,952,269
     
56,386,560
 
                                 
See accompanying notes to unaudited condensed consolidated financial statements.
4

Table of Contents
GLOBAL BLOOD THERAPEUTICS, INC.
Condensed Consolidated Statements of Stockholders’ Equity
(Unaudited)
(In thousands, except share amounts)
    
Common Stock
    
Additional
Paid-
In Capital
   
Accumulated
Other
Comprehensive
Income
    
Accumulated
Deficit
   
Total
Stockholders’
Equity
 
    
Shares
    
Amount
 
Balance at December 31, 2019
   
60,644,380
    $
61
    $
1,316,795
    $
754
    $
(738,916
)   $
578,694
 
Issuance of common stock upon exercise of stock options
   
33,937
     
—  
     
967
     
—  
     
—  
     
967
 
Issuance of common stock upon vesting of restricted share units, net of shares withheld for employee taxes
   
160,594
     
—  
     
(2,099
)    
—  
     
—  
     
(2,099
)
Issuance of common stock pursuant to ESPP purchases
   
47,460
     
—  
     
1,870
     
—  
     
—  
     
1,870
 
Stock-based compensation expense
   
—  
     
—  
     
16,705
     
—  
     
—  
     
16,705
 
Net unrealized gain on marketable securities
   
—  
     
—  
     
—  
     
461
     
—  
     
461
 
Net loss
   
—  
     
—  
     
—  
     
—  
     
(73,026
)    
(73,026
)
                                                 
Balance at March 31, 2020
   
60,886,371
    $
61
    $
1,334,238
    $
1,215
    $
(811,942
)   $
523,572
 
Issuance of common stock upon exercise of stock options
   
334,454
     
—  
     
8,018
     
—  
     
—  
     
8,018
 
Issuance of common stock upon vesting of restricted share units, net of shares withheld for employee taxes
   
110,162
     
—  
     
(74
)    
—  
     
—  
     
(74
)
Stock-based compensation expense
   
—  
     
—  
     
17,128
     
—  
     
—  
     
17,128
 
Net unrealized gain on marketable securities
   
—  
     
—  
     
—  
     
12
     
—  
     
12
 
Net loss
   
—  
     
—  
     
—  
     
—  
     
(52,840
)    
(52,840
)
                                                 
Balance at June 30, 2020
   
61,330,987
    $
61
    $
1,359,310
    $
1,227
    $
(864,782
)   $
495,816
 
                                                 
See accompanying notes to unaudited condensed consolidated financial statements.
5

Table of Contents
    
Common Stock
    
Additional
Paid-
In Capital
   
Accumulated
Other
Comprehensive
Loss
    
Accumulated
Deficit
   
Total
Stockholders’
Equity
 
    
Shares
    
Amount
 
Balance at December 31, 2018
   
55,640,299
    $
56
    $
1,044,941
    $
(48
)   $
(472,150
)   $
572,799
 
Issuance of common stock upon equity offerings, net of issuance costs
   
511,363
     
—  
     
21,246
     
—  
     
—  
     
21,246
 
Issuance of common stock upon exercise of stock options
   
52,288
     
—  
     
817
     
—  
     
—  
     
817
 
Issuance of common stock upon vesting of restricted share units, net of shares withheld for employee taxes
   
78,155
     
 
 
     
(686
)    
—  
     
—  
     
(686
)
Issuance of common stock pursuant to ESPP purchases
   
30,745
     
—  
     
1,128
     
—  
     
—  
     
1,128
 
Vesting of restricted stock purchases
   
24,195
     
—  
     
80
     
—  
     
—  
     
80
 
Stock-based compensation expense
   
—  
     
—  
     
9,453
     
—  
     
—  
     
9,453
 
Net unrealized gain on marketable securities
   
—  
     
—  
     
—  
     
624
     
—  
     
624
 
Net loss
   
—  
     
—  
     
—  
     
—  
     
(48,923
)    
(48,923
)
                                                 
Balance at March 31, 2019
   
56,337,045
    $
56
    $
1,076,979
    $
576
    $
(521,073
)   $
556,538
 
Issuance of common stock upon equity offerings, net of issuance costs
   
3,375,527
     
3
     
192,294
     
—  
     
—  
     
192,297
 
Issuance of common stock upon exercise of stock options
   
123,513
     
1
     
2,331
     
—  
     
—  
     
2,332
 
Issuance of common stock upon vesting of restricted share units, net of shares withheld for employee taxes
   
47,258
     
—  
     
(1,297
)    
—  
     
—  
     
(1,297
)
Vesting of restricted stock purchases
   
22,856
     
—  
     
78
     
—  
     
—  
     
78
 
Stock-based compensation expense
   
—  
     
—  
     
10,948
     
—  
     
—  
     
10,948
 
Net unrealized gain on marketable securities
   
—  
     
—  
     
—  
     
615
     
—  
     
615
 
Net loss
   
—  
     
—  
     
—  
     
—  
     
(57,321
)    
(57,321
)
                                                 
Balance at June 30, 2019
   
59,906,199
    $
60
    $
1,281,333
    $
1,191
    $
(578,394
)   $
704,190
 
                                                 
 
6

Table of Contents
GLOBAL BLOOD THERAPEUTICS, INC.
Condensed Consolidated Statements of Cash Flows
(Unaudited)
(In thousands)
 
Six Months Ended
June 30,
 
 
2020
 
 
2019
 
CASH FLOWS FROM OPERATING ACTIVITIES:
   
     
 
Net loss
  $
(125,866
)   $
(106,244
)
Adjustments to reconcile net loss to net cash used in operating activities:
   
     
 
Depreciation and amortization
   
5,577
     
4,187
 
Amortization (accretion) of premium (discount) on marketable securities
   
(61
)    
(1,204
)
Non-cash
interest expense
   
824
     
—  
 
Amortization of operating lease
right-of-use
assets
   
580
     
212
 
Stock-based compensation
   
32,938
     
20,401
 
Changes in operating assets and liabilities:
   
     
 
Accounts receivables
   
(9,834
)    
—  
 
Inventories
   
(24,926
)    
—  
 
Prepaid expenses and other assets
   
181
     
59
 
Accounts payable
   
(4,918
   
558
 
Accrued liabilities
   
(1,326
)    
6,136
 
Accrued compensation
   
(1,114
)    
(1,795
)
Other liabilities, current
  
 
156
 
 
 
—  
 
Operating lease liabilities
   
1,686
     
(563
)
                 
Net cash used in operating activities
   
(126,103
)    
(78,253
)
                 
CASH FLOWS FROM INVESTING ACTIVITIES:
   
     
 
Purchase of property and equipment
   
(3,918
)    
(548
)
Purchase of marketable securities
   
(57,936
)    
(195,297
)
Maturities of marketable securities
   
261,738
     
120,923
 
                 
Net cash provided by (used in) investing activities
   
199,884
     
(74,922
)
                 
CASH FLOWS FROM FINANCING ACTIVITIES:
   
     
 
Proceeds from issuance of common stock in public offering, net of issuance costs
   
—  
     
213,989
 
Proceeds from issuance of common stock in settlement of employee stock purchase plan and exercise of stock options
   
11,000
     
4,266
 
Payments of debt issuance costs
   
(130
)    
—  
 
Tax paid related to net share settlement of equity awards
   
(2,172
)    
(1,983
)
                 
Net cash provided by financing activities
   
8,698
     
216,272
 
                 
Net increase (decrease) in cash, cash equivalents and restricted cash
   
82,479
     
63,097
 
Cash, cash equivalents and restricted cash at beginning of period
   
304,632
     
277,752
 
                 
Cash, cash equivalents and restricted cash at end of period
  $
387,111
    $
340,849
 
                 
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION:
    
  
 
 
   
 
 
 
Cash paid for interest
   $ 3,419     $ —    
  
 
 
   
 
 
 
SUPPLEMENTAL DISCLOSURES OF
NON-CASH
INVESTING AND FINANCING INFORMATION:
   
     
 
Leasehold improvements paid for by landlord
  $
10,709
    $
851
 
                 
Accrued purchase of property and equipment
  $
3,773
    $
147
 
                 
Accrued issuance costs
  $
(85
)   $
446
 
                 
See accompanying notes to unaudited condensed consolidated financial statements.
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Table of Contents
GLOBAL BLOOD THERAPEUTICS, INC.
Notes to Unaudited Condensed Consolidated Financial Statements
1. Organization and Basis of Presentation
Global Blood Therapeutics, Inc., or the Company, we, us, or our, was incorporated in Delaware in February 2011 and commenced operations in May 2012. We are a biopharmaceutical company dedicated to the discovery, development and delivery of life-changing treatments that provide hope to underserved patient communities. In late November 2019, we received U.S. Food and Drug Administration, or FDA, accelerated approval for our first medicine, Oxbryta
®
(voxelotor) tablets for the treatment of sickle cell disease, or SCD, in adults and children 12 years of age and older. In early December 2019, we began to make Oxbryta available to patients through our special pharmacy partner network. Our principal operations are based in South San Francisco, California, and we operate in one segment.
Need for Additional Capital
In the course of our development activities, we have sustained operating losses and we expect such losses to continue over the next several years. Our ultimate success depends on the outcome of our commercial launch of Oxbryta, research and development and business development activities. Since inception through June 30, 2020, we have incurred cumulative net losses of $864.8 million. We expect to incur additional losses for the foreseeable future to commercialize Oxbryta and conduct product research and development, and expect to potentially raise additional capital to fully implement our business plan. If needed, we intend to raise such capital through borrowings, the issuance of additional equity, and potentially through strategic alliances with partner companies or other transactions. However, if such financing is not available at adequate levels, we will need to
re-evaluate
our operating plans. We believe that our existing cash and cash equivalents and marketable securities will be sufficient to fund our cash requirements for at least twelve months subsequent to the issuance of these financial statements.
2. Summary of Significant Accounting Policies
Basis of Preparation
The accompanying unaudited interim condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America, or U.S. GAAP, and applicable rules and regulations of the Securities and Exchange Commission, or SEC, regarding interim financial reporting. As permitted under those rules, certain footnotes or other financial information that are normally required by U.S. GAAP have been condensed or omitted, and accordingly the balance sheet as of December 31, 2019 has been derived from audited consolidated financial statements at that date but does not include all of the information required by U.S. GAAP for complete financial statements. These unaudited interim condensed consolidated financial statements have been prepared on the same basis as our annual consolidated financial statements and, in the opinion of management, reflect all adjustments (consisting only of normal recurring adjustments) that are necessary for a fair presentation of our financial information. The results of operations for the six months ended June 30, 2020 are not necessarily indicative of the results to be expected for the year ending December 31, 2020 or for any other interim period or for any other future year.
The accompanying unaudited interim condensed consolidated financial statements and related financial information should be read in conjunction with the audited financial statements and the related notes thereto for the year ended December 31, 2019 included in our Annual Report on Form
10-K,
filed with the SEC on February 26, 2020.
Use of Estimates
The preparation of the accompanying consolidated financial statements in accordance with U.S. GAAP requires us to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the consolidated financial statements, and the reported amounts of revenues and expenses during the reporting period. We base our estimates and assumptions on historical experience when available and on various factors that we believe to be reasonable under the circumstances. We evaluate our estimates and assumptions on an ongoing basis. Our actual results could differ from these estimates under different assumptions or conditions.
Concentration of Risk
Credit Risk
We invest in a variety of financial instruments and, by our Board approved investment policy, limit the amount of credit exposure with any one issuer, industry or geographic area for investments other than instruments backed by the U.S. federal government.
8

Table of Contents
Major Customers
We have entered into distribution agreements with certain limited specialty pharmacies and a specialty distributor. For the six months ended June 30, 2020, our two largest customers represented approximately 95% of our product revenue and approximately 94% of our accounts receivable balance at June 30, 2020.
Major Suppliers
We do not currently have any of our own manufacturing facilities, and therefore depend on an outsourced manufacturing strategy for the production of Oxbryta for commercial use and for the production of our product candidates for clinical trials. We have contracts in place with one third-party manufacturer that is approved for the commercial production of Oxbryta and one third-party supplier that is approved for Oxbryta’s active pharmaceutical ingredient. Although there are potential sources of supply other than our existing manufacturers and suppliers, any new supplier would be required to qualify under applicable regulatory requirements.
Principles of Consolidation
The accompanying unaudited interim condensed consolidated financial statements include the accounts of the Company and its wholly-owned subsidiaries. All intercompany transactions and balances have been eliminated upon consolidation.
Significant Accounting Policies
Except as noted below, there have been no material revisions in our significant accounting policies described in Note 2 to the consolidated financial statements included in our Annual Report on Form
10-K
for the year ended December 31, 2019.
Accounting Pronouncements Adopted
In August 2018, the Financial Accounting Standards Board, or FASB, issued Accounting Standards Update, or ASU,
No. 2018-15,
Intangibles—Goodwill and
Other—Internal-Use
Software (Subtopic
350-40),
Customer’s Accounting for Implementation Costs Incurred in a Cloud Computing
Arrangement That Is a Service Contract
, or ASU
2018-15.
ASU
No. 2018-15
requires a customer that is a party to a cloud computing service contract to follow the
internal-use
software guidance in Subtopic
350-40
to determine which implementation costs to capitalize and which costs to expense. The amendments in this update are effective for annual reporting periods beginning after December 15, 2019, and interim periods within those fiscal years. Early adoption of the amendments in this update is permitted. The amendments in this update should be applied either retrospectively or prospectively to all implementation costs incurred after the date of adoption. We adopted ASU
No. 2018-15
in the first quarter of 2020 and applied the guidance prospectively to the implementation costs incurred in our implementations of various cloud computing arrangements that are service contracts. The adoption of this new standard did not have a material impact on our condensed consolidated financial statements.
In August 2018, the FASB issued ASU
No. 2018-13,
Fair Value Measurement (Topic 820)
. The new standard modifies the disclosure requirements on fair value measurements in Topic 820, Fair Value Measurement, including removals of, modification to, and additional disclosure requirements from Topic 820. The amendment of ASU
No. 2018-13
removes disclosure requirements from Topic 820 in the areas of (1) the amount of and reasons for transfers between Level 1 and Level 2 of the fair value hierarchy, (2) the policy for timing of transfers between levels, and (3) the valuation processes for Level 3 fair value measurements. The amendments in this update are effective for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2019. Except for certain amendments related to Level 3 fair value measurements, all the other amendments should be applied retrospectively to all periods presented upon their effective date. Early adoption is permitted upon issuance of ASU
No. 2018-13.
We adopted ASU
No. 2018-13
in the first quarter of 2020 and applied the guidance retrospectively. The adoption of this new standard did not have a material impact on our condensed consolidated financial statements.
In June 2016, the FASB issued ASU
No. 2016-13,
Measurement of Credit Losses on Financial Instruments (Topic 326)
, which amends the guidance on the impairment of financial instruments. The new standard adds to U.S. GAAP an impairment model that is based on expected losses rather than incurred losses, which is known as the current expected credit loss, or CECL model. The CECL model applies to most debt instruments (other than those measured at fair value), trade and other receivables, financial guarantee contracts, and loan commitments.
Available-for-sale
debt securities are scoped out of this guidance. Our investment portfolio primarily consists of
available-for-sale
debt securities carried at fair value. Our accounts receivable do not have long terms and we do not expect to write off accounts receivable. The amendments in this update are effective for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2019. Early adoption of the amendments in this update is permitted. We adopted ASU
No. 2016-13
in the first quarter of 2020 and applied the guidance prospectively. The adoption of this new standard did not have a material impact on our condensed consolidated financial statements.
 
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Table of Contents
3. Fair Value Measurements
Fair value accounting is applied for all financial assets and liabilities that are recognized or disclosed at fair value in the consolidated financial statements on a recurring basis (at least annually). Our financial instruments consist of cash and cash equivalents, marketable securities, accounts receivables, accounts payable and accrued liabilities. Cash and cash equivalents, marketable securities and restricted cash are reported at their respective fair values on our condensed consolidated balance sheets. The remaining financial instruments are reported on our condensed consolidated balance sheets at cost that approximate current fair values due to their relatively short maturities.
Assets and liabilities recorded at fair value on a recurring basis in the condensed consolidated balance sheets are categorized based upon the level of judgment associated with the inputs used to measure their fair values. Fair value is defined as the exchange price that would be received for an asset or an exit price that would be paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. The authoritative guidance on fair value measurements establishes a three-tier fair value hierarchy for disclosure of fair value measurements as follows:
Level 1 –
Inputs are unadjusted, quoted prices in active markets for identical assets or liabilities at the measurement date;
Level 2
Inputs are observable, unadjusted quoted prices in active markets for similar assets or liabilities, unadjusted quoted prices for identical or similar assets or liabilities in markets that are not active, or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the related assets or liabilities; and
Level 3 –
Unobservable inputs that are significant to the measurement of the fair value of the assets or liabilities that are supported by little or no market data.
The following table summarizes our financial assets measured at fair value on a recurring basis (in thousands):
 
 
June 30, 2020
 
 
Total
 
 
Level 1
 
 
Level 2
 
 
Level 3
 
Financial Assets:
   
     
     
     
 
Money market funds
  $
384,515
    $
384,515
    $
 
 
    $
 —  
 
Corporate debt securities
   
84,046
     
—  
     
84,046
     
—  
 
U.S. government agency securities
   
43,524
     
—  
     
43,524
     
—  
 
Certificates of deposits
   
3,899
     
—  
     
3,899
     
—  
 
U.S. government securities
   
58,025
     
—  
     
58,025
     
—  
 
                                 
Total financial assets
  $
574,009
    $
384,515
    $
189,494
    $
 —  
 
                                 
 
 
December 31, 2019
 
 
Total
 
 
Level 1
 
 
Level 2
 
 
Level 3
 
Financial Assets:
   
     
     
     
 
Money market funds
  $
250,535
    $
250,535
    $
—  
    $
 —  
 
Corporate debt securities
   
152,149
     
—  
     
152,149
     
—  
 
U.S. government agency securities
   
95,032
     
—  
     
95,032
     
—  
 
Certificates of deposits
   
6,282
     
—  
     
6,282
     
—  
 
U.S. government securities
   
140,244
     
—  
     
140,244
     
—  
 
                                 
Total financial assets
  $
644,242
    $
250,535
    $
393,707
    $
 —  
 
                                 
We estimate the fair values of our investments in corporate debt securities, government and government related securities and certificates of deposits by taking into consideration valuations obtained from third-party pricing services. The fair value of our marketable securities classified within Level 2 is based upon observable inputs that may include benchmark yields, reported trades, broker/dealer quotes, issuer spreads,
two-sided
markets, benchmark securities, bids, offers and reference data including market research publications. At June 30, 2020 and December 31, 2019, the weighted average remaining contractual maturities of our Level 2 investments was less than one year and all of these investments are rated
A-1/P-1
or A/A2, or higher, by Moody’s and
 
Standard
 
and Poor’s.
 
10

Table of Contents
4.
Available-for-Sale
Securities
Estimated fair values of
available-for-sale
securities are generally based on prices obtained from commercial pricing services. The following table is a summary of
available-for-sale
securities recorded in cash and cash equivalents, restricted cash, or marketable securities in our condensed consolidated balance sheets (in thousands):
 
June 30, 2020
   
December 31, 2019
 
 
Amortized
Cost
 
 
Unrealized
Gains
 
 
Unrealized
(Losses)
 
 
Estimated Fair
Value
 
 
Amortized
Cost
 
 
Unrealized
Gains
 
 
Unrealized
(Losses)
 
 
Estimated Fair
Value
 
Financial Assets:
   
     
     
     
     
     
     
     
 
Money market funds
  $
384,515
    $
— 
    $
 — 
    $
384,515
    $
250,535
    $
 — 
    $
 — 
    $
250,535
 
Corporate debt securities
   
83,385
     
661
     
— 
     
84,046
     
151,773
     
384
     
(8
)    
152,149
 
U.S. government agency securities
   
43,418
     
108
     
(2
)    
43,524
     
94,963
     
73
     
(4
)    
95,032
 
Certificates of deposits
   
3,868
     
31
     
— 
     
3,899
     
6,239
     
43
     
— 
     
6,282
 
U.S. government securities
   
57,596
     
429
     
— 
     
58,025
     
139,978
     
266
     
— 
     
140,244
 
                                                                 
Total
  $
572,782
    $
1,229
    $
(2
)   $
574,009
    $
643,488
    $
766
    $
(12
)   $
644,242
 
                                                                 
The following table summarizes the classification of the
available-for-sale
securities on our condensed consolidated balance sheets (in thousands):
 
June 30, 2020
 
 
December 31, 2019
 
Cash and cash equivalents
  $
384,516
    $
251,480
 
Short-term marketable securities
   
156,014
     
307,732
 
Long-term marketable securities
   
33,479
     
85,030
 
                 
Total
  $
574,009
    $
644,242
 
                 
We do not intend to sell the investments that are in an unrealized loss position, and it is unlikely that we will be required to sell the investments before recovery of their amortized cost basis, which may be maturity. We have determined that the gross unrealized losses on our marketable securities were temporary in nature during the periods presented.
5. Balance Sheet Components
Inventories
We began capitalizing inventories in November 2019 once the FDA approved Oxbryta. Inventories consist of the following (in thousands):
 
June 30, 2020
 
 
December 31, 2019
 
Raw materials
  $
10,210
    $
700
 
Work-in-process
   
15,617
     
525
 
Finished goods
   
1,507
     
52
 
                 
Total inventories
  $
27,334
    $
1,277
 
                 
Property and Equipment, Net
Property and equipment consists of the
following
(in thousands):
 
June 30, 2020
 
 
December 31, 2019
 
Laboratory equipment
  $
11,612
    $
8,314
 
Computer equipment
   
2,600
     
2,224
 
Leasehold improvements
   
32,231
     
13,785
 
Construction-in-progress
   
515
     
19,289
 
                 
Total property and equipment
   
46,958
     
43,612
 
Less: accumulated depreciation and amortization
   
(7,290
)    
(16,499
)
                 
Property and equipment, net
  $
39,668
    $
27,113
 
                 
 
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Table of Contents
Accrued liabilities
Accrued liabilities consist of the following (in thousands):
 
June 30, 2020
 
 
December 31, 2019
 
Accrued research and development costs
  $
6,951
    $
26,480
 
Accrued manufacturing costs
   
23,782
     
9,466
 
Accrued professional and consulting services
   
3,283
     
4,564
 
Accrued sales deductions
   
5,302
     
529
 
Other
   
4,415
     
319
 
                 
Total accrued liabilities
  $
43,733
    $
41,358
 
                 
Other liabilities, current
Other liabilities consist of the following (in thousands):
 
June 30, 2020
 
 
December 31, 2019
 
Operating lease liabilities, current
  $
3,486
    $
1,866
 
Other payable
   
30
     
30
 
                 
Total other liabilities, current
  $
3,516
    $
1,896
 
                 
6. Long-term Debt
Term Loan
On December 17, 2019, we entered into the Loan Agreement, or Term Loan, with funds managed by Pharmakon Advisors LP, which are BioPharma Credit PLC, as collateral agent, Biopharma Credit Investments V (Master) LP, as a lender, and BPCR Limited Partnership, as a lender, and collectively, the Lenders, for a senior secured credit facility consisting of an initial tranche of $75.0 million and the option to draw an additional $75.0 million until December 31, 2020. The first tranche, in the amount of $75.0 million, was funded in connection with the closing date of the Term Loan in December 2019. In June 2020, in accordance with the terms of the Loan Agreement, we provided notification to Lenders of our intention to draw the second tranche of the Term Loan, in the amount of $75.0 million, prior to December 31, 2020, subject to certain closing conditions. As of June 30, 2020, the second tranche of the Term Loan has not been drawn.
The Term Loan carries a
72-month
term. The Term Loan bears interest at a floating per
annum
interest rate equal to 7.00% plus the greater of (a) the
3-month
LIBOR rate and (b) 2%. In the event we default, the interest rate would be 3% above the rate that is otherwise applicable thereto. Interest on amounts outstanding are payable quarterly in arrears. The Term Loan repayment schedule provides for interest only payments for the first 39 months, followed by consecutive equal quarterly payments of principal and interest commencing in March 2023 and continuing through the maturity of December 2025.
We have the option to prepay all or a portion of the borrowed amounts under the Term Loan. If we exercise this option, we must pay a prepayment fee between 1% and 3% of the principal amount being prepaid depending on the timing of the prepayment, or Prepayment Fee. If the prepayment occurs before December 2022, we must also pay an amount equal to the sum of all interest that would have accrued and been payable from date of prepayment through December 2022, or Make Whole Amount. We are obligated to pay an additional fee to the Lenders determined by multiplying the principal amount being paid or prepaid multiplied by 2%, or Paydown Fee, when such payments are made.
In the event of default or change in control, all unpaid principal and all accrued and unpaid interest amounts (if any) become immediately due and payable, at which point, we will be subject to the Prepayment Fee, the Make Whole Amount (if any) and the Paydown Fee. Events of default include, but are not limited to, a payment default, a material adverse change, and insolvency. The obligations under the Term Loan are secured by a first priority security interest in and a lien on substantially all of our assets, subject to certain exceptions.
 
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Debt issuance costs paid directly to the Lenders of $1.1 million and the other debt issuance costs of $0.4 million were accounted for as discounts on the Term Loan. These debt discounts along with the Paydown Fee are being amortized or accreted to interest expenses throughout the life of the Term Loan using the effective interest rate method. As of June 30, 2020, there were unamortized issuance costs and debt discounts of $1.4 million, which were recorded as a direct deduction from the Term Loan on the condensed consolidated balance sheet. In addition, we paid the Lenders $1.1 million for the option to draw the additional $75 million, which was capitalized as a deferred asset and which is included in other assets, current and amortized on a straight-line basis through December 31, 2020. As of June 30, 2020, the unamortized fee for the option to draw the additional funds was $0.6 million.
Future payments of principal and interest on the Term Loan as of June 30, 2020 were as follows (in thousands):
Year ending December 31,
 
Amount
 
2020 (six months)
  $
3,375
 
2021
   
6,750
 
2022
   
6,750
 
2023
   
31,406
 
2024
   
29,156
 
2025
   
26,906
 
         
Total minimum payments
   
104,343
 
Less amount representing interest
   
(27,843
)
Less amount representing Paydown Fee
   
(1,500
)
         
Long-term debt, gross
   
75,000
 
Discount on notes payable
   
(1,411
)
Accretion of Paydown Fee
   
186
 
         
Long-term debt
  $
73,775
 
         
7. Commitments and Contingencies
Leases
We have operating leases for our headquarters, where we have office and research and development laboratory facilities, and equipment. Our leases have remaining lease terms of 1 to 10 years. Most of these leases require monthly lease payments that may be subject to annual increases throughout the lease term. Certain of these leases include renewal options at our election, with renewal terms that can extend the lease term from 1 to 10 years. These optional periods have not been considered in the determination of the
right-of-use,
or ROU, assets or lease liabilities associated with these leases as we did not consider it reasonably certain that we would exercise the options.
Lease costs included in operating expenses in the consolidated statement of operations in relation to these operating leases were $3.1 million and $1.4 million for the three months ended June 30, 2020 and 2019, respectively; and $6.2 million and $3.3 million for the six months ended June 30, 2020 and 2019, respectively. Included in these lease costs were variable lease costs, which were not included within the measurement of our operating ROU assets and operating lease liabilities in the amount of $0.6 million and $0.4 million for the three months ended June 30, 2020 and 2019, respectively; and $1.3 million and $1.3 million
 
for
the six months ended June 30, 2020 and 2019, respectively. The variable lease cost is comprised primarily of our proportionate share of operating expenses, property taxes, and insurance in relation with our facility lease. These costs are classified as operating lease expense due to our election to not separate lease and non-lease components.
 
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Supplemental cash flow information related to leases for the period reported is as follows (in thousands, except weighted-average remaining lease term and weighted-average discount rate):
 
 
Six Months Ended June 30,
 
 
    2020    
 
 
    2019    
 
ROU assets obtained in exchange for new operating lease
  $
205
  
    $
14,177
 
Cash paid for amounts included in the measurement of lease liabilities
   
2,590
     
2,235
 
Weighted-average remaining lease term of operating leases (in years)
   
9.7
     
8.4
 
Weighted-average discount rate of operating leases
   
8.7
%    
13.2
%
 
The majority of our lease costs are driven by our operating lease for our headquarters in South San Francisco, where we have office and research and development laboratory facilities.
In March 2017, we entered into a noncancelable operating lease, or
Original
Lease,
 
for approximately 67,185 square feet of space in South San Francisco, California, or Prior Premises. The
Original
Lease term commenced in November 2017 as we gained control over physical access to the Prior Premises. We acquired $11.1 million of leasehold improvements at the Prior Premises with the tenant inducement allowance provided under the
Original
Lease. We are required to repay $1.7 million of the tenant inducement allowance
, or Initial Allowance,
to the landlord in the form of additional monthly rent with interest applied over the term of the
Original
Lease.
In August 2018, we entered into an amendment to the
Original
Lease, or Lease Amendment, to relocate the leased premises from the
 
Prior Premises to a
to-be-constructed
building consisting of approximately 164,150 rentable square feet of space, or Substitute Premises. The date on which we became responsible for paying rent under the Lease Amendment was March 13, 2020, or the Substitute Premises Payment Commencement Date. The Lease Amendment has a contractual term, or Substitute Premises Term, of 10 years from the Substitute Premises Payment Commencement Date, which was subsequently determined to be in March 2020. The Lease Amendment grants us an option to extend the Lease Amendment for an additional
10-year
period. Future minimum rental payments under the Lease Amendment during the
10-year
term are $121.5 million in the aggregate. Under the Lease Amendment, we are obligated to pay to the landlord certain costs, including taxes and operating expenses. On October 1, 2019, we determined that the Lease Amendment for the Substitute Premises had commenced as we had the right to control the Substitute Premises. The Lease Amendment also provides a tenant inducement allowance of up to $27.9 million, of which $4.1 million, if utilized, would be repaid to the landlord in the form of additional monthly rent with interest applied. As of June 30, 2020, we have capitalized $32.2 million of costs in leasehold improvements within property and equipment, net for construction of leasehold improvements at the Substitute Premises, which were mostly acquired with the tenant inducement provided under the Lease Amendment.
We vacated the Prior Premises and surrendered and delivered the Prior Premises to the landlord in May 2020, upon which time we had no further obligations with respect to the Prior Premises
other than with respect to the Initial Allowance, which we will repay to the landlord in the form of additional monthly rent with interest applied over the term of the Original Lease
. Upon signing of the Lease Amendment, we re-evaluated the remaining useful life of the leasehold improvements at the Prior Premises and started to amortize the leasehold improvements over the remaining period of expected use, resulting in an acceleration of depreciation expenses for approximately
$3.8 million and $3.4 million for the six months ended June 30, 2020 and 2019, respectively.
As of June 30, 2020, the maturities of our operating lease liabilities were as follows (in thousands):
Year ending December 31,
 
Amount
 
2020 (
six
months)
  $
4,837 
 
2021
   
11,822
 
2022
   
12,202
 
2023
   
12,564
 
2024
   
12,927
 
2025
   
13,347
 
Thereafter
   
61,146
 
         
Total lease payments
   
128,845
 
Less: Imputed interest 
   
(43,456
)
         
Present value of operating lease liabilities
  $
85,389
 
         
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Contingencies
In the ordinary course of business, we may be subject to legal claims and regulatory actions that could have a material adverse effect on our business or financial position. We assess our potential liability in such situations by analyzing potential outcomes, assuming various litigation, regulatory and settlement strategies. If we determine a loss is probable and its amount can be reasonably estimated, we accrue an amount equal to the estimated loss.
No losses and no provision for a loss contingency have been recorded to date.
8. Stock-Based Compensation
We have three stock-based compensation plans
the Amended and Restated 2017 Inducement Equity Plan, or 2017 Inducement Plan, the
Amended and Restated
2015 Stock Option and Incentive Plan, or 2015 Plan, and the 2012 Stock Option and Grant Plan, or 2012 Plan. As of June 30, 2020, there were 1,628,836 shares reserved under the 2017 Inducement Plan and 4,522,527 shares reserved under the 2015 Plan for the future issuance of equity awards. Upon adoption of the 2015 Plan in July 2015, no new awards or grants are permitted under the 2012 Plan. See Note 10 to the Consolidated Financial Statements included in our Annual Report on Form
10-K
for the year ended December 31, 2019 for additional information related to these stock-based compensation plans.
Stock Options
The following summarizes option activity under the 2017 Inducement Plan, 2015 Plan and 2012 Plan:
 
Number of
Options
 
 
Weighted-
Average
Exercise Price
 
Outstanding
 
 
December 31, 2019
   
3,573,860
    $
36.24
 
Options granted
   
666,633
     
65.91
 
Options exercised
   
(368,391
)    
24.39
 
Options canceled
   
(297,650
)    
52.93
 
                 
Outstanding
 
 
June 30, 2020
   
3,574,452
    $
41.61
 
                 
The fair values of stock options granted to employees were calculated using the following assumptions:
 
 
Three Months Ended
June 30,
   
Six Months Ended
June 30,
 
 
2020
 
 
2019
 
 
2020
 
 
2019
 
Expected term (in years)
   
5.1-6.1
     
5.3-6.1
     
5.1-6.1
     
5.3-6.1
 
Volatility
   
71.0%-71.8%
     
70.5%-71.7%
     
69.6%-71.8%
     
70.5%-72.2%